梅州城区体检人群高尿酸血症与代谢综合征相关性研究

【外文题名】Investigation of Relationship of Hyperuricemia with Metabolic Syndrome in Physical Examination Population in Meizhou City

【作者】 丘梓华

【关键词】 高尿酸血症 代谢综合征 相关性 梅州 客家人

【外文关键词】 Hyperuricemia metablolic syndrome relationship Meizhou City Hakka people

【导师姓名】冯烈

【学位名称】硕士

【学位年度】2011

【学位授予单位】暂无

【所属分类】R589.7,R589

【录入时间】2011-01-01

【全文挂接】 知网挂接 读秀挂接

【摘要】指南制订联合委员会推荐的标准。利用Logistic回归分析尿酸的影响因素及其与代谢综合征及其各组分的关系。结果：研究一、高尿酸血症的患病情况及相关因素分析1、高尿酸血症的患病率20.1%,其中男性22.2%,女性12.3%(p<0.001)；且男性尿酸水平显著高于女性[(356.43±86.16) umol/L, (269.31±79.64) umol/L, p<0.0001]。2、高尿酸血症的发生率随着年龄增长而升高(趋势性检验p<0.0001),且不同性别结果相同。3、高尿酸血症伴发疾病中以血脂异常最为常见(82.4%),其次为超重和肥胖(75.0%)、腹型肥胖(24.7%)、糖尿病(17.6%)、高血压(13.2%)。4、Logistie回归分析显示：年龄(OR=1.12,95%CI:1.09-1.21)、男性(OR=1.47,95%CI: 1.13-2.53)、肥胖(OR=3.67,95%CI:2.20-6.12)、腹型肥胖(OR=3.59,95%CI:2.18-5.90)、高血糖(OR=1.98,95%CI:1.41-3.43)、高TG血症(OR=1.82,95%CI:1.04-2.49)、高TC血症(OR=3.05,95%CI:2.17-4.74)、低HDL-C血症(OR=1.25,95%CI:1.01-1.74)、高血压(OR=1.14,95%CI:1.11-1.87)、饮酒(OR=1.45,95%CI:1.21-1.65)、高嘌呤饮食(OR=1.14, 95%CI:1.07-1.83)与高尿酸血症升高相关。研究二、尿酸水平与代谢综合征各组分的相关性研究1、代谢综合征组高尿酸血症的发生率为38.1%,而非代谢综合征组的发生率为16.3%,差异统计学意义(p<0.01)。进一步分析发现不管是代谢综合征组还是非代谢综合男性高尿酸血症的发生率均高于女性,且差异有统计学意义(p<0.01)。2、尿酸水平随着代谢综合征组分数的增加而增加,线性趋验有统计学意义(p<0.01)3、按研究人群的尿酸四分位数分析发现代谢综合征的发生率分别为3.9%,9.2%,17.1%,26.8%,趋势检验有统计学意义(p<0.01)。分性别分析时结果与总人群的相同。4、尿酸水平均随着BMI、腰围、甘油三酯、总胆固醇、血糖、血压升高而升高(p<0.01),但随着HDL-C升高无明显变化。5、分析不同尿酸水平与代谢综合征各组分的关系发现：随着尿酸水平的升高,肥胖、腹型肥胖、高甘油三酯、血糖异常发生率亦逐渐上升(趋势性检验p<0.001),低HDL-C血症发生率未见上述趋势。结论：随着生活水平的提高,生活习惯的改变,梅州城区体检人群高尿酸血症的患病率较高。高血糖、高甘油三酯血症、高胆固醇血症、低高密度脂蛋白血症、年龄、男性、高血压、肥胖、高嘌呤饮食、饮酒可能为高尿酸血症的危险因素。血尿酸水平与代谢综合征及其各组分(肥胖、血脂异常、高血压、血糖异常)之间关系密切。因此,高尿酸血症可能是代谢综合征发生发展的重要因素。...

【外文摘要】Objective::To investigate prevalent characteristic of hyperuricemia and the relationship between hyperuricemia and metablolic syndrome.Methods:Investigate the physical examination population of MeiZhou People’s Hospital between January,2010 and June,2010. Diagnosis criterion of hyperuricemia is based on the Diagnosis and Cure Guide of the Primary gout designed by Chinese Medical Association, and the diagnosis criterion of metablolic syndrome followed the criterion recommended by the association which focused on adult un-normal blood-fat defence-cure. Logistic regression analysis was used to determine the relationship between uric acid and metabolics syndrome and its components.Results:Study 1 Investigation of prevalent rate of hyperuricemia and its risk factors1、The prevalence of hyperuricemia was 20.1%,22.2% for man and 12.3% for women, respectively(p<0.001).The mean level of uric acid in males was higher significantly than that in the females[(356.43±86.16) umol/L, (269.31±79.64) umol/L,P<0.0001].2、The prevalent rate of hyperuricernia increased with the age(trend test p<0.0001). Similar trend can be seen in male and female population.3、The main concomitant diseases of hyperuricemia were hyperlipemia(82.4%), then over weight and obesity(75.0%), abdomen obesity(24.7%), diabetes(17.6%), and hypertension ((13.2%),4、In a logistic regression model, age(OR=1.12,95%CI:1.09-1.21),male gender(OR=1.47, 95%CI:1.13-2.53),obesity(OR=3.67,95%CI:2.20-6.12),abdomen obesity(OR=3.59, 95%CI:2.18-5.90),hyperglycaemia(OR=1.98,95%CI:1.41-3.43),hypertriglyceridemia(OR=1.82,9 5%CI:1.04-2.49),hypercholesteremia(OR=3.05,95%CI:2.17-4.74), hypo-high-density-lipoproteinemia (OR=1.25,95%CI:1.01-1.74), hypertension (OR=1.14, 95%CI:1.11-1.87), alcohol (OR=1.45,95%CI:1.21-1.65) and the purine diet (OR=1.14,95%CI: 1.07-1.83) were associated with increased risk of hyperuricemia.Study 2 Relationship of serum uric acid concentration with metabolic syndrome and its components 1、The prevalent rate of hyperuricemia that was significantly higher in MS group was 38.1%. The prevalent rate of hyperuricemia that was significantly higher in non-MS group was 16.3%. The prevalent rate of hyperuricemia was significantly higher in MS group than that in non-MS group (p<0.01). Not only in MS group but also in non-MS group the man had higher proportion of hyperuricemia than the female.2、The level of uric acid was increasing with the number of the components of MS (liner trend for p<0.01)3、The prevalence of MS was3.9%,9.2%,17.1%,26.8% across the interquartiles (liner trend for p 0.0001). Similar trend can be seen in male and female population.4、Correlation analysis demonstrated that serum uric acid level was positively correlated with BMI,waist, triglyceride, total cholesterol, creatinine, blood pressure, but had no connection with HDL-C.5、With the increase of the level of uric acid, the proportion of hypertension, obesity, abdomen obesity, high triglyceride, abnormal glucose increased significantly (p<0.0001). Similar trend could not be seen in low HDL-C.Conelusion:As the development of economy and the change of living habits, the prevalence of hyperuricemia was higher in in physical examination population in Meizhou City.The statistical significant risk factors for hyperuricemia were hyperglycaemia,high triglyceride, high total cholesterol, hypo-high-density-lipoproteinemia,age, male gender, hypertension,obesity, purine diet and alcoho。Serum uric acid intimately related with metabolic syndrome and its components such as obesity, dyslipdemia and so on. So high uric acid level maybe an important factor of the MS....